Hear about high efficiency fibroblast reprogramming using the INCOGNITO™ iPSCMax™ Ψ-mRNA Reprogramming Mix.

Watch this presentation to discover clean, efficient oligo adenylation workflows.

Learn how to optimize mRNA design with INCOGNITO™ T7 mScript™ Complete Production Systems.

We present new accurate same-day methods we have developed for measuring mRNA characteristics using simple benchtop electrophoretic separation formats.

We discuss the impacts of dsRNA in RNA production and strategies to enhance translation and reduce immunogenicity.

The presence of double-stranded RNA (dsRNA) in mRNA preparations is a well-established trigger of innate immune responses primarily through activation of pattern recognition receptors such as Toll-like receptor 3.

Messenger RNA (mRNA) therapeutics require precise control of structural and biochemical attributes to ensure stability, translation efficiency, and minimal immunogenicity.

An essential step in manufacturing high-quality mRNA is to perform comprehensive quality control (QC) prior to use in downstream applications. Evaluating
5′-capping efficiency and 3′-poly(A) tail length is vital for producing high-quality mRNA.

Self-amplifying RNAs (saRNAs) are engineered derivatives of positive-sense single-stranded RNA viruses in which viral structural protein-coding sequences are replaced with a gene of interest.

CELLSCRIPT™’s dual workflow combining N1-methyl-pseudouridine (N1meΨ) modification with enzymatic dsRNA removal achieves high mRNA performance.

TempliAMP™ RCA Kit delivers the most efficient yield-to-time ratio amongst competitor kits.

Featured at RNATx Symposium. Messenger RNA (mRNA) and self-amplifying RNA (saRNA) technologies continue to show transformative potential across therapeutic fields, including engineered cell therapies and cell reprogramming, where precise control over immunogenicity is critical for success.

Featured at ASGCT 2026. Messenger RNA (mRNA) technologies continue to show transformative potential across therapeutic fields, including engineered cell therapies and cell reprogramming, where precise control over immunogenicity is critical for success.

Featured at TIDES USA 2026. EZ-QC™ mRNA Assay Kits produce results comparable to LC-MS and offer a convenient, flexible, and cost-effective approach to mRNA QC.

Learn how to optimize mRNA design with INCOGNITO™ T7 mScript™ Complete Production Systems.

The EZ-QC™ mRNA Assay kits facilitate easy, affordable, and accurate methods to determine the 5′ cap and 3′ polyadenylation status of mRNA using standard laboratory equipment.

The Adenylator™ DNA/RNA 5′-Adenylation Kit provides a superior alternative to traditional adenylation methods.

Pairing chemical uridine modification with enzymatic dsRNA removal yields high-quality, immunogenicity-free mRNA.

Róisin McGuigan, Editor, Nucleic Acid Insights, speaks to Ryan Lahr, Senior R&D Scientist, CELLSCRIPT™, about design, production, and quality control of synthesized mRNA for translation in cells.

Explore essential steps and design strategies to optimize mRNA synthesis for therapeutic success.